Title of article :
Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST
Author/Authors :
Bonacorso، نويسنده , , Helio G. and Porte، نويسنده , , Liliane M.F. and Navarini، نويسنده , , Jussara and Paim، نويسنده , , Gisele R. and Luz، نويسنده , , Fلbio M. and Oliveira، نويسنده , , Lenon M. and Whietan، نويسنده , , Carson W. and Martins، نويسنده , , Marcos A.P. and Zanatta، نويسنده , , Nilo، نويسنده ,
Abstract :
In this study, diethylaminosulfur trifluoride (DAST) was successfully applied in monofluorination reactions of some trifluoromethyl substituted 2-hydroxy-2H-chromenones, employing a general, mild, and efficient methodology. The fluorinated compounds (2-fluoro-2H-chromenones) were synthesized as unique products by a chemoselective reaction in 63–81% yield despite the presence of different reactive sites subjected to reactions with DAST.
