Title of article
Studies on the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles
Author/Authors
Bruschi، نويسنده , , Simone and Moccia، نويسنده , , Maria and Adamo، نويسنده , , Mauro F.A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
3602
To page
3604
Abstract
We have investigated the reactivity of 3-methyl-4-nitro-5-styrylisoxazoles with S-nucleophiles. This study revealed that the title compounds were optimal Michael acceptors toward thiols. A procedure was also established to prepare isoxazole-containing sulfides in one-pot and without the use of chromatography. Isoxazole-containing sulfides were converted into the corresponding sulfones in high yield.
Keywords
Multicomponent synthesis , 4-Nitroisoxazoles , Polyfunctional scaffolds
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878711
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