Author/Authors :
Since، نويسنده , , Marc and Khoumeri، نويسنده , , Omar and Verhaeghe، نويسنده , , Pierre and Maillard-Boyer، نويسنده , , Martine and Terme، نويسنده , , Thierry and Vanelle، نويسنده , , Patrice، نويسنده ,
Abstract :
We report herein the first example of a SNAr reaction using TDAE-initiated carbanions in quinazoline series. The o-nitrobenzyl carbanion, formed by the action of TDAE on o-nitrobenzyl chloride, reacts with 4-chloro-2-trihalomethylquinazolines 4 and 5 via a SNAr mechanism. This enabled a new series of 4-benzyl-2-trihaloquinazoline derivatives to be synthesized in good yields under mild reaction conditions offering promising prospects for pharmacomodulation.
Keywords :
TDAE , 4-Chloroquinazolines , SNAr , o-Nitrobenzyl chloride , o-Nitrobenzyl carbanion
