Concise synthesis of Bacillus anthracis exosporium tetrasaccharide via two-stage activation of allyl glycosyl donor strategy

A highly efficient glycosylation protocol recently developed in our laboratory has been utilized in the short synthesis of the tetrasaccharide 1, an antigen important to the development of carbohydrate-based diagnostic tools and vaccines against anthrax. The protocol employs allyl glycosides as building blocks and improves the overall synthetic efficiency.