Title of article :
Enzymatic resolution of trans-2-hydroxycyclohexanecarbonitrile in supercritical carbon dioxide
Author/Authors :
Utcz?s، نويسنده , , Margita and Székely، نويسنده , , Edit and Forr?، نويسنده , , Enik? and Sz?ll?sy، نويسنده , , ?ron and Fül?p، نويسنده , , Ferenc and Sim?ndi، نويسنده , , Béla، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A novel, highly enantioselective (E ≫ 100) and environmentally benign method is presented for the kinetic resolution of trans-2-hydroxycyclohexanecarbonitrile in supercritical carbon dioxide. Using Candida antarctica Lipase B as a biocatalyst and vinyl acetate as an acyl donor, enantiomerically pure (1S,2R)-acetoxycyclohexanecarbonitrile and (1R,2S)-hydroxycyclohexanecarbonitrile were obtained in quantitative yields and excellent ee (98%) values.
Keywords :
Supercritical carbon dioxide , Lipase , kinetic resolution , Enantioselective acylation , Hydroxycyclohexanecarbonitrile
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
