Title of article
Spectroscopical study of bacteriopurpurinimide–naphthalimide conjugates for fluorescent diagnostics and photodynamic therapy
Author/Authors
Panchenko، نويسنده , , Pavel A. and Sergeeva، نويسنده , , Antonina N. and Fedorova، نويسنده , , Olga A. and Fedorov، نويسنده , , Yuri V. and Reshetnikov، نويسنده , , Roman I. and Schelkunova، نويسنده , , Anastasiya E. and Grin، نويسنده , , Mikhail A. and Mironov، نويسنده , , Andrey F. and Jonusauskas، نويسنده , , Gediminas، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
5
From page
140
To page
144
Abstract
Two novel bis(chromophoric) dyads ABPI–NI1 and ABPI–NI2 containing 1,8-naphthalimide and bacteriopurpurinimide units linked by p-phenylene-methylene (ABPI–NI1) and pentamethylene (ABPI–NI2) spacers were prepared to test their ability to be used in the design of effective agents for both photodynamic therapy (PDT) and fluorescent tumor imaging. Photophysical studies revealed that the emission from the naphthalimide chromophore in both conjugates was partially quenched due to resonance energy transfer between the photoactive components. Compound ABPI–NI2 with more sterically flexible oligomethylene group demonstrated higher fluorescence intensity as compared with that for ABPI–NI1.
Keywords
PM6 semiempirical calculations , 1 , 8-Naphthalimide , Conjugate , Fluorescence imaging , resonance energy transfer , Bacteriopurpurinimide , photodynamic therapy
Journal title
Journal of Photochemistry and Photobiology B:Biology
Serial Year
2014
Journal title
Journal of Photochemistry and Photobiology B:Biology
Record number
1878860
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