Title of article
Hydrosiloxane–Ti(OiPr)4: an efficient system for the reduction of primary amides into primary amines as their hydrochloride salts
Author/Authors
Laval، نويسنده , , Stéphane and Dayoub، نويسنده , , Wissam and Pehlivan، نويسنده , , Leyla and Métay، نويسنده , , Estelle and Favre-Réguillon، نويسنده , , Alain and Delbrayelle، نويسنده , , Dominique and Mignani، نويسنده , , Gérard and Lemaire، نويسنده , , Marc، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
4072
To page
4075
Abstract
A simple and useful method for the reduction of primary amides into the corresponding amines using a polymethylhydrosiloxane (PMHS)–Ti(OiPr)4 reducing system is described. Aromatic as well as aliphatic primary amides are reduced in high selectivity and excellent yields. The reduction could proceed via dehydration of the primary amide group into the corresponding nitrile which is then reduced into the corresponding primary amine.
Keywords
Amines , primary amides , Reduction , Polymethylhydrosiloxane (PMHS) , Titanium
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1878913
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