Author/Authors :
Laval، نويسنده , , Stéphane and Dayoub، نويسنده , , Wissam and Pehlivan، نويسنده , , Leyla and Métay، نويسنده , , Estelle and Favre-Réguillon، نويسنده , , Alain and Delbrayelle، نويسنده , , Dominique and Mignani، نويسنده , , Gérard and Lemaire، نويسنده , , Marc، نويسنده ,
Abstract :
A simple and useful method for the reduction of primary amides into the corresponding amines using a polymethylhydrosiloxane (PMHS)–Ti(OiPr)4 reducing system is described. Aromatic as well as aliphatic primary amides are reduced in high selectivity and excellent yields. The reduction could proceed via dehydration of the primary amide group into the corresponding nitrile which is then reduced into the corresponding primary amine.
Keywords :
Amines , primary amides , Reduction , Polymethylhydrosiloxane (PMHS) , Titanium
