Title of article :
An expedient synthesis of cis/trans-1,3-disubstituted cyclobutanols
Author/Authors :
Calad، نويسنده , , Stacie and Mans، نويسنده , , Douglas and Morin، نويسنده , , Justin-Alexander and O’Neill-Slawecki، نويسنده , , Stacy and Sisko، نويسنده , , Joseph، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
A two-step procedure is described to access 3-alkoxycyclobutanones from chloroacetyl chloride utilizing a step-wise [2+2] ketene cycloaddition followed by catalytic hydrogenation to reduce the α-chlorine in a single reaction sequence. The resulting cyclobutanones can be readily converted into a variety of cis or trans-1,3-disubstituted aminocyclobutanols and cyclobutanediols.
Keywords :
3-Disubstituted , Chloroacetyl chloride , Cyclobutanone , Hydrogenolysis , 1 , Cyclobutanol , ketene , +
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
