Title of article
Asymmetric synthesis of (E)-dehydroapratoxin A
Author/Authors
Ma، نويسنده , , Jing-Yi and Huang، نويسنده , , Wei and Wei، نويسنده , , Bang-Guo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
4598
To page
4601
Abstract
An asymmetric approach to key intermediate 17 starting from lactone 7 is described, in which Evan’s alkylation and CBS-catalyzed reduction are used for construction of the chiral centers, respectively. Thus, the synthesis of (E)-dehydroapratoxin A 6 could be accomplished in a general fashion, therein FDPP has been proven as an efficient condensation reagent for the coupling of amine 25 and carboxylic acid 24.
Keywords
depsipeptide , Marine cyanobacteria , Apratoxin , total synthesis , macrolactamization
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879144
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