Title of article
Highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids by addition of benzylzinc reagents to chiral imines of trifluoropyruvate
Author/Authors
Yang، نويسنده , , Jie and Min، نويسنده , , Qiao-Qiao and He، نويسنده , , Yi and Zhang، نويسنده , , Xingang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
4675
To page
4677
Abstract
An effective and facile method for highly diastereoselective synthesis of quaternary α-trifluoromethyl α-amino acids was developed in good yields with high diastereoselectivity (dr >20:1) via MgCl2-accelerated addition of benzylzinc reagents (Knochel type organozinc reagents) to (R)-phenylglycinol methyl ether based imines of trifluoropyruvate.
Keywords
Benzylzinc reagents , diastereoselective synthesis , Ketoimine esters , Quaternary ?-trifluromethyl ?-amino acids , trifluoropyruvate
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879170
Link To Document