Title of article :
Premnalatifolin A, a novel dimeric diterpene from Premna latifolia Roxb
Author/Authors :
Suresh، نويسنده , , G. and Suresh Babu، نويسنده , , K. and Suri Appa Rao، نويسنده , , M. and Rama Subba Rao، نويسنده , , V. and Ashok Yadav، نويسنده , , P. and Lakshma Nayak، نويسنده , , V. V. S. Ramakrishna، نويسنده , , Sistla، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
Premnalatifolin A (1), a unique icetexane diterpene dimer was isolated from the stem-bark of Indian medicinal plant, Premna latifolia. Its structure and relative stereochemistry were elucidated on the basis of detailed spectroscopic analysis, including HRESIMS and 2D NMR (COSY, HSQC, HMBC, and NOESY) spectra. The compound has dimeric carbon skeleton composed of two icetexane skeletal diterpenes linked via ether bond. Further, premnalatifolin A (1) was also evaluated for its cytotoxicity against cancer cell lines (HT-29, A-431, MCF-7, Hep-G2, PC-3, A-549, B-16 F10, and ACHN), which displayed potent activity against HT-29 and MCF-7 cell lines with the IC50 values of 12.15 and 1.11 μg/mL, respectively.
Keywords :
Icetexane diterpenes , cytotoxic activity , Cancer cell lines , Premna latifolia
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
