Title of article
An improved stereoselective total synthesis of (R)-rugulactone
Author/Authors
Goswami، نويسنده , , Abhishek and Saikia، نويسنده , , Partha Pratim and Saikia، نويسنده , , Bishwajit and Chaturvedi، نويسنده , , Devdutt and Barua، نويسنده , , Nabin C.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
5133
To page
5135
Abstract
A novel route for the stereoselective total synthesis of (R)-rugulactone 1 has been developed, starting from substituted epoxide 4 and 3-phenylpropionaldehyde 5 employing Julia-Kocienski olefination as a key step to construct E-configured α,β-unsaturated keto-group. The overall yield of the synthesized rugulactone is 19.94% and is better than the reported methods.
Keywords
Rugulactone , ?-Pyranon-2-one , NF-?B inhibitor , Julia-Kocienski olefination
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879309
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