Title of article :
Synthesis of [1,2,4,5]tetrazino[6′,1′:2,3]imidazo[4,5-c]isoquinolin-5-ones by microwave-assisted three-component reaction
Author/Authors :
Pellegatti، نويسنده , , Laurent and Vedrenne، نويسنده , , Emeline and Hiebel، نويسنده , , Marie-Aude and Buron، نويسنده , , Frédéric and Massip، نويسنده , , Stéphane and Leger، نويسنده , , Jean-Michel and Jarry، نويسنده , , Christian and Routier، نويسنده , , Sylvain، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
An efficient and original Ugi multicomponent reaction of aminopyridines and aminopyrimidines is reported. Starting from aminotetrazine 6 or 7, an isocyanide and an ortho-carboxybenzaldehyde, tetrazinoimidazoisoquinolinones were isolated, after few minutes of microwave irradiation, in good to excellent yields. The scope of this method was extended by using different isocyanides.
Keywords :
multicomponent reaction , heterocycle , microwave irradiation , isocyanide , Ugi reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
