Title of article
Remarkable synergistic effect between MonBI and MonBII on epoxide opening reaction in ionophore polyether monensin biosynthesis
Author/Authors
Sato، نويسنده , , Kyohei and Minami، نويسنده , , Atsushi and Ose، نويسنده , , Toyoyuki and Oguri، نويسنده , , Hiroki and Oikawa، نويسنده , , Hideaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
5277
To page
5280
Abstract
Enzymatic epoxide-opening cascade is one of the key biosynthetic processes for constructing structurally diverse polyethers. Here we report the first in vitro analysis of the cyclization catalyzed by two epoxide hydrolases, MonBI and MonBII involved in monensin biosynthesis, using simple epoxy-alcohols and the unprecedented synergistic effect on the epoxide-opening activity between these epoxide hydrolases.
Keywords
Epoxide-opening cascades , epoxide hydrolase , Polyether , monensin
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879344
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