Author/Authors :
Just، نويسنده , , Matthew J. and Tekkam، نويسنده , , Srinivas and Alam، نويسنده , , Mohammad A. and Jonnalagadda، نويسنده , , Subash C. and Johnson، نويسنده , , Joseph L. and Mereddy، نويسنده , , Venkatram R. Atigadda، نويسنده ,
Abstract :
Novel stereoselective synthesis of α-methylene-β-substituted pyroglutamates, and α-alkylidene-pyroglutamates has been achieved via substrate controlled asymmetric alkylation of l-threonine derived oxazole with Baylis–Hillman reaction based allyl bromides and acetates, respectively. The synthesized compounds were evaluated for their proteasome inhibition and cytotoxicity on multiple myeloma cells.
Keywords :
Substrate controlled alkylation , Baylis–Hillman bromides/acetates , Pyroglutamates (?-carboxy-?-lactams) , threonine , oxazoles
