Title of article
A convergent synthesis of the immunosuppressant FTY720 employing aqueous Wittig chemistry
Author/Authors
Calzavara، نويسنده , , Janice and McNulty، نويسنده , , James، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
5672
To page
5675
Abstract
A short, convergent synthesis of the immunosuppressant FTY720 is described involving the use of 4-hydroxymethylbenzaldehyde as a pivotal intermediate. A double Wittig strategy was developed to connect this dual-functional aldehyde with an alkyl-tether and to a readily available TRIS-derivative leading to an efficient synthesis of the target molecule.
Keywords
aqueous chemistry , FTY720 , immunosuppressant , Multiple sclerosis , Wittig reaction
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879440
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