Title of article
A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-one core
Author/Authors
Hay، نويسنده , , Duncan A. and Adam، نويسنده , , Fiona M. and Bish، نويسنده , , Gerwyn and Calo، نويسنده , , Frederick and Dixon، نويسنده , , Rachel and Fray، نويسنده , , M. Jonathan and Hitchin، نويسنده , , James and Jones، نويسنده , , Peter and Paradowski، نويسنده , , Michael and Parsons، نويسنده , , Gemma C. and Proctor، نويسنده , , Katie J.W. and Pryde، نويسنده , , David C. and Smith، نويسنده , , Nichola، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
5728
To page
5732
Abstract
A flexible route which enables access to derivatives of 4-amino-1,3-dihydroimidazo[4,5-c]pyridin-2-ones is described. Issues of selectivity, reaction safety, and low yields in original routes are overcome with the key improvements to the route, including a Negishi cross-coupling and use of a carbamate as a protecting group and intrinsic carbonyl source. The new route enables variation of C-6 and N-1 substituents.
Keywords
TLR7 , negishi , Carbamates , Heterocycles
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879452
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