Title of article
Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales
Author/Authors
Ayers، نويسنده , , Sloan and Ehrmann، نويسنده , , Brandie M. and Adcock، نويسنده , , Audrey F. and Kroll، نويسنده , , David J. and Wani، نويسنده , , Mansukh C. and Pearce، نويسنده , , Cedric J. and Oberlies، نويسنده , , Nicholas H.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
5733
To page
5735
Abstract
As part of our ongoing investigation of filamentous fungi for anticancer leads, an active fungal extract was identified from the Mycosynthetix library (MSX 55526; from the Order Sordariales). Bioactivity-directed fractionation yielded the known ergosterol peroxide (2) and 5α,8α-epidioxyergosta-6,9(11),22-trien-3β-ol (3), and a new benzoate trimer, termed thielavin B methyl ester (1). The structure elucidation of 1 was facilitated by the use of HRMS coupled to an APPI (atmospheric pressure photoionization) source. Compound 1 proved to be moderately active against a panel of three cancer cell lines.
Keywords
cytotoxicity , fungi , Thielavin , APPI , benzoate
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879453
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