Title of article
A facile N-arylation of acetanilides with arynes
Author/Authors
Haber، نويسنده , , James C. and Lynch، نويسنده , , Michael A. and Spring، نويسنده , , Stacey L. and Pechulis، نويسنده , , Anthony D. and Raker، نويسنده , , Joseph and Wang، نويسنده , , Yi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
5847
To page
5850
Abstract
An efficient, mild and transition-metal-free method for the N-arylation of acetanilides, leading to a range of unsymmetrical diarylamine products is reported. Reactions of ortho-silylaryl triflates with acetanilides in the presence of tetrabutylammonium triphenyldifluorosilicate (TBAT) in toluene afforded the desired products in good to excellent yields. Regioselectivity was also observed when unsymmetrical aryne precursors were used.
Keywords
Tetrabutylammonium triphenyldifluorosilicate , N-Arylation , arynes , ortho-Silylaryl triflates , Acetanilides
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879481
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