Title of article
Synthesis of 1,2,3-triazole moiety-containing NAD analogs and their potential as redox cofactors
Author/Authors
Hou، نويسنده , , Shuhua and Liu، نويسنده , , Wujun and Ji، نويسنده , , Debin and Wang، نويسنده , , Qian and Zhao، نويسنده , , Zongbao (Kent) Zhao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
5855
To page
5857
Abstract
Thirteen 1,2,3-triazole moiety-containing NAD analogs were synthesized and evaluated as redox cofactors. Noticeable enzymatic activities were observed when these analogs were employed as cofactors for malic enzyme or alcohol dehydrogenase. Our results indicated that the natural NAD-dependent oxidoreductases possessed flexible NAD binding pockets.
Keywords
promiscuity , malic enzyme , alcohol dehydrogenase , NAD analogs
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879483
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