Modular synthesis of mono, di, and tri-1,4-disubstituted-1,2,3-triazoles through copper-mediated alkyne–azide cycloaddition

The synthesis of 1,2,3-triazoles was developed employing sequential copper azide–alkyne cycloaddition, tosylation, sodium azide, and copper azide–alkyne steps. This approach allowed the synthesis of two and three 1,2,3-triazole rings. A preliminary study to gain further insight into the reaction was performed using in situ ReactIR technology.