Title of article
Hydroxymethylation of α-substituted nitroacetates
Author/Authors
Ji، نويسنده , , Cong-Bin and Liu، نويسنده , , Yun-Lin and Cao، نويسنده , , Zhong-Yan and Zhang، نويسنده , , Yi-Yu and Zhou، نويسنده , , Jian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
6118
To page
6121
Abstract
Only 1 mol % of K3PO4 is efficient enough to catalyze the hydroxymethylation of α-substituted nitroacetates in good to excellent yield. Both aliphatic and aryl substituted nitroacetates work well under this reaction. The first catalytic asymmetric version of this reaction also reported that 10 mol % of cupreidine could catalyze this reaction up to 71% ee and 89% yield. Paraformaldehyde and formalin could both serve as the hydroxymethylation C1 unit. The synthetic application of products is also demonstrated.
Keywords
Tetrasubstituted carbon , Hydroxymethylation , ?-Substituted nitroacetates
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879547
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