Title of article
Highly enantioselective bioreduction of ethyl 3-oxohexanoate
Author/Authors
Ramos، نويسنده , , Aline de Souza and Ribeiro، نويسنده , , Joyce Benzaquem and Lopes، نويسنده , , Raquel de Oliveira and Leite، نويسنده , , Selma Gomes Ferreira and Souza، نويسنده , , Rodrigo Octavio Mendonça Alves de، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
3
From page
6127
To page
6129
Abstract
Seven wild-type microorganism strains were used to reduce ethyl 3-oxohexanoate to ethyl (R)-3-hydroxyhexanoate. Free cells of Kluyveromyces marxianus and Aspergillus niger led to higher than 99% of conversion with higher than 99% ee. After immobilization in calcium alginate spheres, cells of K. marxianus exhibited high enantioselectivity (>99% ee) and conversion level (99%) within 24 h even if substrate was added at concentration of 10 g/L (62 mM).
Keywords
Immobilization , biotransformation , chiral reduction , kluyveromyces marxianus , ?-Ketoester
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879549
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