Title of article
A synthesis of bredinin (Mizoribine®) from an acyclic precursor
Author/Authors
Humble، نويسنده , , Robert W. and Middleton، نويسنده , , Danielle F. and Banoub، نويسنده , , Joseph and Ewing، نويسنده , , David F. and Boa، نويسنده , , Andrew N. and Mackenzie، نويسنده , , Grahame، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
5
From page
6223
To page
6227
Abstract
Bredinin (4-carbamoyl-1-β-d-ribofuranosylimidazolium-5-olate, 1) was synthesised by the formation of a malonamate from 2,3-isopropylidene-d-ribofuranosylamine and ethyl malonyl chloride, followed by a sequence involving amination, via reduction of an oxime, heterocycle formation and then deprotection.
Keywords
5-Hydroxyimidazole , Cyclisation , nucleoside
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879574
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