Author/Authors :
Lopes، نويسنده , , Luciane C. and Roman، نويسنده , , Bianca and Medeiros، نويسنده , , Maria A. and Mukhopadhyay، نويسنده , , Abhik and Utrilla، نويسنده , , Pilar and Gلlvez، نويسنده , , Julio and Mauriٌo، نويسنده , , Sofيa Garcيa and Moltiva، نويسنده , , Virginia and Lourenço، نويسنده , , Ana and Feliciano، نويسنده , , Arturo San Feliciano، نويسنده ,
Abstract :
Cernumidine and isocernumidine were identified in the ethanol extract of the leaves of Solanum cernuum Vell. together with four known phenolic compounds. The alkaloids have a natural (2-aminopyrrolidin-1-yl)carboxamidine alkaloidal base acylated with isoferulic (3-hydroxy-4-methoxycinnamic) acid with Z and E configurations, respectively. The structures were elucidated on the basis of 1D- and 2D-NMR data and the structure of cernumidine was confirmed by X-ray analysis. Cernumidine displayed inhibition of interleukin-8 production by HT-29 colon carcinoma cells. This fact could orient further research in gastric cancer prevention and treatment.
Keywords :
Alkaloids , Cernumidines , Solanum cernnum Vell. , interleukin-8
