Title of article
Cernumidine and isocernumidine, new type of cyclic guanidine alkaloids from Solanum cernuum
Author/Authors
Lopes، نويسنده , , Luciane C. and Roman، نويسنده , , Bianca and Medeiros، نويسنده , , Maria A. and Mukhopadhyay، نويسنده , , Abhik and Utrilla، نويسنده , , Pilar and Gلlvez، نويسنده , , Julio and Mauriٌo، نويسنده , , Sofيa Garcيa and Moltiva، نويسنده , , Virginia and Lourenço، نويسنده , , Ana and Feliciano، نويسنده , , Arturo San Feliciano، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
6392
To page
6395
Abstract
Cernumidine and isocernumidine were identified in the ethanol extract of the leaves of Solanum cernuum Vell. together with four known phenolic compounds. The alkaloids have a natural (2-aminopyrrolidin-1-yl)carboxamidine alkaloidal base acylated with isoferulic (3-hydroxy-4-methoxycinnamic) acid with Z and E configurations, respectively. The structures were elucidated on the basis of 1D- and 2D-NMR data and the structure of cernumidine was confirmed by X-ray analysis. Cernumidine displayed inhibition of interleukin-8 production by HT-29 colon carcinoma cells. This fact could orient further research in gastric cancer prevention and treatment.
Keywords
Alkaloids , Cernumidines , Solanum cernnum Vell. , interleukin-8
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879613
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