Title of article :
Copper-catalyzed coupling of imidazoles and pyrazoles with 1,1-dibromo-1-alkenes: a distinct approach for direct N-alkynylation of heteroarenes
Author/Authors :
Das، نويسنده , , Biswanath and Salvanna، نويسنده , , N. and Reddy، نويسنده , , Gandolla Chinna and Balasubramanyam، نويسنده , , Penagaluri Balasubramanyam، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Abstract :
The direct N-alkynylation of heteroarenes, imidazoles, and pyrazoles with 1,1-dibromo-1-alkene has been carried out for the first time using [Cu(Phen)PPh3Br] (as a catalyst) and Cs2CO3 in DMSO at 80 °C. The products are formed in good to high yields (66–85%) within 3 h. No side products could be detected.
Keywords :
Imidazole , N-Alkynylation , Pyrazole , 1 , 1-Dibromo-1-alkene , H
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
