Title of article
Tandem Henry/oxa-Michael route to the 1,3-disubstituted-1,3-dihydrobenzo[c]furan system
Author/Authors
Luzzio، نويسنده , , Frederick A. and Okoromoba، نويسنده , , Otome E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
6530
To page
6533
Abstract
The reaction of ortho-formyl cinnamates and ortho-formyl-α-benzalketones with suitably substituted alkylnitro compounds in the presence of 1,1,3,3-tetramethylguanidine results in the formation of 1,3-disubstituted dihydroisobenzofurans. The reaction mechanism entails a base-mediated nitronate addition to the aryl formyl group followed by intramolecular alcoholate addition to the unsaturated component that then affords the isobenzofuran system.
Keywords
isobenzofurans , Henry reaction , 1 , 1 , 3 , Heck reaction , Alkylnitro compounds , 3-Tetramethylguanidine
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879646
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