Author/Authors :
Kato، نويسنده , , Hikaru and Nakamura، نويسنده , , Yuichi and Finefield، نويسنده , , Jennifer M. and Umaoka، نويسنده , , Hideharu and Nakahara، نويسنده , , Takashi and Williams، نويسنده , , Robert M. and Tsukamoto، نويسنده , , Sachiko، نويسنده ,
Abstract :
Two reverse-prenylated indole alkaloids, deoxybrevianamide E and 6-hydroxydeoxybrevianamide E, are proposed as biosynthetic precursors for advanced metabolites isolated from the marine-derived Aspergillus sp. In order to uncover the role of the alkaloids in the biosynthetic pathway, the feeding experiments of the [13C]2–[15N]-labeled deoxybrevianamide E and 6-hydroxydeoxybrevianamide E were performed to afford the metabolites, which were produced by oxidation and successive pinacol-type rearrangement of the isoprenyl units.
