Title of article :
Synthesis and cross coupling of a highly substituted 2-pyridylboronate: application to the large scale synthesis of a mineralocorticoid antagonist
Author/Authors :
Boos، نويسنده , , Charles and Bowles، نويسنده , , Daniel M. and Cai، نويسنده , , Cuiman and Casimiro-Garcia، نويسنده , , Agustin and Chen، نويسنده , , Xiangyang and Hulford، نويسنده , , Catherine A. and Jennings، نويسنده , , Sandra M. and Jason Kiser، نويسنده , , E. W. Piotrowski، نويسنده , , David W. and Sammons، نويسنده , , Matthew and Wade، نويسنده , , Robert A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2011
Pages :
5
From page :
7025
To page :
7029
Abstract :
The large scale synthesis of functionalized 2-pyridylboronate 8 and optimization of its Suzuki–Miyaura coupling to chloropyrazoline (R)-7 to provide a scalable synthesis of mineralocorticoid antagonist (R)-1 is described.
Keywords :
Suzuki–Miyaura coupling , 2-Pyridylboronate , pyrazoline , Large-scale synthesis
Journal title :
Tetrahedron Letters
Serial Year :
2011
Journal title :
Tetrahedron Letters
Record number :
1879768
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1879768
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