Title of article
l-Prolinamide derivatives as efficient organocatalysts for aldol reactions on water
Author/Authors
Tang، نويسنده , , Gongkun and Hu، نويسنده , , Xianming and Altenbach، نويسنده , , Hans Josef، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2011
Pages
4
From page
7034
To page
7037
Abstract
A series of l-prolinamide derivatives have been evaluated as potential organocatalysts for aldol reactions. To synthesize these catalysts, a novel and simple route has been developed using proline N-carboxyanhydride (proline-NCA). A new catalyst with a trifluoromethyl-sulfonamide group has been found exhibiting excellent diastereoselectivity (anti/syn: 97/3) and enantioselectivity (99% ee) with 10 mol % loading and being easily recyclable in water.
Keywords
aldol reaction , organocatalysis , Proline amide derivative , Proline-NCA , Enantioselecitvity
Journal title
Tetrahedron Letters
Serial Year
2011
Journal title
Tetrahedron Letters
Record number
1879770
Link To Document