Author/Authors :
Feng، نويسنده , , Lili and Karpinski، نويسنده , , Piotr H. and Sutton، نويسنده , , Paul and Liu، نويسنده , , Yugang and Hook، نويسنده , , David F. and Hu، نويسنده , , Bin and Blacklock، نويسنده , , Thomas J. and Fanwick، نويسنده , , Philip E. and Prashad، نويسنده , , Mahavir and Godtfredsen، نويسنده , , Sven and Ziltener، نويسنده , , Christoph، نويسنده ,
Abstract :
LCZ696 displays several surprising features, such as an intrinsic stabilization of the supramolecular complex by monovalent multi-coordinated sodium cations and water molecules. In addition, to the best of our knowledge, the compound is the first example of a dual-acting pharmaceutical built as a supramolecular complex delivering two pharmacologic effects—angiotensin receptor 1 (AT1) blockage and neprilysin (NEP) inhibition.
Keywords :
LCZ696 , hypertension , ARNI , X-ray crystallography , Supramolecular complex
