Title of article
Synthesis of Entecavir (BMS-200475)
Author/Authors
Zhou، نويسنده , , Bing and Li، نويسنده , , Yuanchao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
3
From page
502
To page
504
Abstract
A synthesis of Entecavir (BMS-200475) was achieved starting from 1,3-propanediol in 15 steps and 23.4% overall yield. A unique feature of the synthetic route is that the five-membered carbocyclic core is installed by an intramolecular nitrile oxide cycloaddition (INOC) reaction and the guanine moiety is introduced by a Mitsunobu reaction. The route is characteristic of low cost, high yield and easy operation.
Keywords
Intramolecular nitrile oxide cycloaddition , Entecavir , BMS-200475 , hepatitis B virus , Highly diastereoselective
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880024
Link To Document