Title of article
Asymmetric synthesis of phosphonotrifluoroalanine and its derivatives using N-tert-butanesulfinyl imine derived from fluoral
Author/Authors
Rِschenthaler، نويسنده , , Gerd-Volker and Kukhar، نويسنده , , Valery P. and Kulik، نويسنده , , Irine B. and Belik، نويسنده , , Michael Yu. and Sorochinsky، نويسنده , , Alexander E. and Rusanov، نويسنده , , Eduard B. and Soloshonok، نويسنده , , Vadim A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
539
To page
542
Abstract
Addition of dialkyl phosphites to (S)-N-tert-butanesulfinyl imine derived from fluoral afforded, under mild conditions, the corresponding N-tert-butanesulfinyl α-aminophosphonates in moderate to high yields and diastereoselectivity. The major diastereomers of N-tert-butanesulfinyl α-aminophosphonates of (SS,S) configuration were isolated, and after partial or complete deprotection, converted into enantiomerically pure phosphonotrifluoroalanine and its dialkyl esters.
Keywords
imines , Phosphites , Aminophosphonic acids , asymmetric synthesis , fluorine , Addition
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880033
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