Author/Authors :
Wu، نويسنده , , Xing-De and He، نويسنده , , Juan and Shen، نويسنده , , Yu and Dong، نويسنده , , Liao-Bin and Pan، نويسنده , , Zhenghong and Xu، نويسنده , , Gang and Gong، نويسنده , , Xun and Song، نويسنده , , Liu-Dong and Leng، نويسنده , , Ying and Li، نويسنده , , Yan and Peng، نويسنده , , Liyan and Zhao، نويسنده , , Qin-Shi، نويسنده ,
Abstract :
Three novel triterpenoids, pseudoferic acids A and B (1 and 2) possessed a unique 16,24-cyclo-26-norlanostane skeleton, and pseudoferic acid C (3) featured a cis-fused D/E-ring system, were isolated from the root bark of Pseudolarix kaempferi. Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 2 and 3 exhibited weak inhibitory activities against 11β-HSD1 (11β-hydroxysteroid dehydrogenase 1) with IC50 values of 0.44 (mouse 11β-HSD1) and 0.75 μM (human 11β-HSD1), respectively.
