Title of article
A facile domino protocol for the stereoselective synthesis of trans-2,3-dihydrobenzofurans and cis-5,6-dihydrofuro[2,3-d]pyrimidines
Author/Authors
Beer Mohamed Vinosha، نويسنده , , Beermohamed and Perumal، نويسنده , , Subbu and Renuga، نويسنده , , Subbiah and Almansour، نويسنده , , Abdulrahman I.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
962
To page
966
Abstract
A facile protocol for the stereoselective construction of trans-2,3-dihydrobenzofurans and cis-5,6-dihydrofuro[2,3-d]pyrimidines from the reactions of 2,2′-sulfonylbis(1,3-diarylprop-2-en-1-ones) with cyclic 1,3-diketones, viz. cyclohexane-1,3-diones, barbituric acid, and 2-thioxodihydropyrimidine-4,6(1H,5H)-dione in the presence of DBU in ethanol is described. This transformation presumably occurs via domino Michael addition-proton exchange-annulation via intramolecular displacement sequence.
Keywords
stereoselectivity , 2?-Sulfonylbis(1 , annulation , Domino reaction , trans-2 , 2 , Michael addition , 3-diarylprop-2-en-1-ones) , 3-Dihydrobenzofurans
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880153
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