Author/Authors :
Sousa، نويسنده , , Carlos A.D. and Rizzo-Aguiar، نويسنده , , Fabio and Vale، نويسنده , , M. Luيsa C. and Garcيa-Mera، نويسنده , , Xerardo and Caamaٌo، نويسنده , , Olga and Rodrيguez-Borges، نويسنده , , José E.، نويسنده ,
Abstract :
A route to selective functionalization of polyhydroxypyrrolidines is described. The method is based on orthogonal protection/deprotection along the process of synthesis of the referred pyrrolidines, which consist in hydroxylation of the double bond of 2-azabicyclo[2.2.1]hept-5-enes followed by its oxidative cleavage and in situ reduction of the intermediate dialdehyde. The synthesis of a novel N-hydroxypyrrolidine is also described.
Keywords :
Polyhydroxypyrrolidines , Orthogonal protection , Selective Functionalization , Azasugar
