Title of article
Biocatalytic production of tetrahydroisoquinolines
Author/Authors
Ruff، نويسنده , , Bettina M. and Br?se، نويسنده , , S. and O’Connor، نويسنده , , Sarah E.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
1071
To page
1074
Abstract
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.
Keywords
Pictet–Spengler reaction , Norcoclaurine synthase , Tetrahydroisoquinoline alkaloids , Biocatalysis
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880189
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