Title of article :
Biocatalytic production of tetrahydroisoquinolines
Author/Authors :
Ruff، نويسنده , , Bettina M. and Br?se، نويسنده , , S. and O’Connor، نويسنده , , Sarah E.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
The promiscuity of the enzyme norcoclaurine synthase is described. This biocatalyst yielded a diverse array of substituted tetrahydroisoquinolines by cyclizing dopamine with various acetaldehydes in a Pictet–Spengler reaction. This enzymatic reaction may provide a biocatalytic route to a range of tetrahydroisoquinoline alkaloids.
Keywords :
Pictet–Spengler reaction , Norcoclaurine synthase , Tetrahydroisoquinoline alkaloids , Biocatalysis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
