Title of article :
New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives
Author/Authors :
Pastor، نويسنده , , Joaquيn and Rodrيguez-Arيstegui، نويسنده , , Sonsoles and Hernلndez، نويسنده , , Ana Isabel and Varela، نويسنده , , Carmen and Salgado، نويسنده , , Antonio and Martيnez، نويسنده , , Sonia، نويسنده ,
Abstract :
First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein.
