Title of article
Microwave-mediated synthesis and manipulation of a 2-substituted-5-aminooxazole-4-carbonitrile library
Author/Authors
Spencer، نويسنده , , John and Patel، نويسنده , , Hiren and Amin، نويسنده , , Jahangir and Callear، نويسنده , , Samantha K. and Coles، نويسنده , , Simon J. and Deadman، نويسنده , , John J. and Furman، نويسنده , , Christophe and Mansouri، نويسنده , , Roxane and Chavatte، نويسنده , , Philippe and Millet، نويسنده , , Régis، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
1656
To page
1659
Abstract
A 2-substituted-5-aminooxazole-4-carbonitrile library has been synthesised and modified via microwave-mediated and flow chemistries. One synthesised compound, 5-(1H-pyrrol-1-yl)-4-(1H-tetrazol-5-yl)-2-(thien-2-yl)oxazole, contains three distinct heterocycles attached to the central oxazole core, highlighting the structural diversity of this approach. Three oxazoles had micromolar ki values against cannabinoid (CB1/CB2) receptors.
Keywords
Microwave-assisted synthesis , Parallel synthesis , Flow chemistry , oxazoles
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880357
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