Author/Authors :
Chen، نويسنده , , Yu-Hsin and Lu، نويسنده , , Mei-Chin and Chang، نويسنده , , Yu-Chia and Hwang، نويسنده , , Tsong-Long and Wang، نويسنده , , Wei-Hsien and Weng، نويسنده , , Ching-Feng and Kuo، نويسنده , , Jimmy and Sung، نويسنده , , Ping-Jyun، نويسنده ,
Abstract :
A novel ubiquinone derivative, pseudoalteromone A (1), possessing a 9C nor-monoterpenoid moiety was produced from a marine bacterium Pseudoalteromonas sp. CGH2XX. This bacterium is originally isolated from a cultured-type octocoral Lobophytum crassum. The structure of ubiquinone 1 was established by spectroscopic methods. Pseudoalteromone A (1) exhibited significant cytotoxicity toward the MOLT-4 (human acute lymphoblastic leukemia, IC50 = 3.764 μg/mL) cells and displayed a significant inhibitory effect (inhibition rate 45.1%) on the release of elastase by human neutrophils at a concentration of 10 μg/mL.
Keywords :
Ubiquinone , Pseudoalteromonas , Pseudoalteromone , cytotoxicity , elastase , Lobophytum
