Title of article :
Auxiliary-directed oxidation of ursolic acid by ‘Ru’-porphyrins: chemical modulation of cytotoxicity against tumor cell lines
Author/Authors :
Tanaka، نويسنده , , Katsunori and Mazumder، نويسنده , , Kishor and Siwu، نويسنده , , Eric R.O. and Nozaki، نويسنده , , Satoshi and Watanabe، نويسنده , , Yasuyoshi and Fukase، نويسنده , , Koichi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2012
Abstract :
Derivatization of ursolic acid, one of the natural ursene-type pentacyclic triterpenes, was investigated by the oxidation with dioxoruthenium(VI) tetraphenylporphyrins. Oxidation selectivity on the terpene structure was modulated by the auxiliaries introduced on the tetraphenylporphyrin. Chemical oxidation of the ursolic acid affected the cytotoxic activity against tumor cell lines.
Keywords :
Ursolic acid , Dioxoruthenium(VI) tetraphenylporphyrin , cytochrome P450 , Biomimetic oxidation , cytotoxicity
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
