Author/Authors :
Illera، نويسنده , , Diana Salazar and Suresh، نويسنده , , Surisetti and Moccia، نويسنده , , Maria and Bellini، نويسنده , , Gea and Saviano، نويسنده , , Michele and Adamo، نويسنده , , Mauro F.A.، نويسنده ,
Abstract :
We describe the development of an N-heterocyclic carbene catalysed homoenolate addition to 4-nitro-5-styrylisoxazoles to give substituted cyclopentanones with a unique substitution pattern and as single diastereoisomers. The synthetic utility of the cyclopentanones obtained was briefly explored through their conversion into α-fluorinated diketones and keto acids.
Keywords :
homoenolate , N-Heterocyclic carbenes , Polyfunctional scaffolds , 4-Nitroisoxazoles
