Author/Authors :
Fehler، نويسنده , , Stefanie K. and Pratsch، نويسنده , , Gerald and Huber، نويسنده , , Walter and Gast، نويسنده , , Alain and Hochstrasser، نويسنده , , Remo and Hennig، نويسنده , , Michael C Heinrich، نويسنده , , Markus R.، نويسنده ,
Abstract :
3-Aryltyramines were prepared in one single step from tyramine and various arenediazonium salts by radical arylation. Binding as well as enzyme inhibition data of the 14 compounds do not prove true interaction with BACE-1. In contrast, with BACE-2 inhibition and binding could be confirmed indicating that 3-aryltyramines are potential starting points for a drug discovery effort.
Keywords :
radical reactions , BACE , Tyramine , Biaryl , arylation
