Highly stereoselective palladium-catalyzed Heck coupling of 5-iodouridine-5′-triphosphates with allylamine: a new efficient method for the synthesis of (E)-5-aminoallyl-uridine-5′-triphosphates

The palladium-catalyzed Heck coupling of 5-iodouridine-5′-triphosphates with allylamine is described. The reaction is highly stereoselective that results in high purity of (E)-5-aminoallyl-uridine-5′-triphosphate with good yields.