Title of article
1,3-Dipolar cycloaddition of a chiral nitrone to (E)-1,4-dichloro-2-butene: a new efficient synthesis of (2S,3S,4R)-4-hydroxyisoleucine
Author/Authors
Aouadi، نويسنده , , Kaïss and Jeanneau، نويسنده , , Erwann and Msaddek، نويسنده , , Moncef and Praly، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
2817
To page
2821
Abstract
1,3-Dipolar cycloaddition of a chiral nitrone derived from (−)-menthone to (E)-1,4-dichlorobut-2-ene was the key step in a novel 5 step synthesis of (2S,3S,4R)-4-hydroxyisoleucine, obtained in 21% overall yield with high enantiopurity.
Keywords
3-dipolar cycloaddition , Chiral nitrone , 1 , 4-hydroxyisoleucine , Isoxazolidines , menthone
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880853
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