Author/Authors :
Ren، نويسنده , , Yunlai and Dong، نويسنده , , Chuanhua and Zhao، نويسنده , , Shuang and Sun، نويسنده , , Yanpei and Wang، نويسنده , , Jianji and Ma، نويسنده , , Junying and Hou، نويسنده , , Chaodong، نويسنده ,
Abstract :
Copper-based catalysts were firstly introduced into the cyanation of benzyl chlorides with non-toxic K4[Fe(CN)6]. The presented method avoids the use of extremely poisonous alkali cyanides and precious palladium catalysts. No other reagent apart from CuI, K4[Fe(CN)6] and toluene was used in the cyanation, showing that the presented protocol is simple and practical. A series of benzyl chlorides were smoothly cyanated in up to 85% yield under the optimal conditions.
Keywords :
cyanation , Copper , Benzyl chlorides , Potassium hexacyanoferrate(II)
