Title of article
A novel scalable and stereospecific synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones
Author/Authors
Hitchin، نويسنده , , James R. and Hamilton، نويسنده , , Niall M. and Jordan، نويسنده , , Allan M. and Lyons، نويسنده , , Amanda J. and Ogilvie، نويسنده , , Donald J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
5
From page
2868
To page
2872
Abstract
A novel scalable stereoselective synthesis of 3α- and 3β-amino-5α-androstan-17-ones and 3α- and 3β-amino-5α-pregnan-20-ones has been developed using phthalimide based Mitsunobu chemistry. In all four cases, the products were isolated as single diastereoisomers in high chemical yield and purity without the need for chromatography at any stage in their syntheses.
Keywords
Steroid , stereoselectivity , Mitsunobu reaction , Phthalimide , scalability
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880878
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