Title of article
A simple protocol for the synthesis of triazole-linked cyclic glycopeptidomimetics: a sequential Ugi-MCR and azide–alkyne cycloaddition approach
Author/Authors
Samarasimhareddy، نويسنده , , M. and Hemantha، نويسنده , , Hosahalli P. and Sureshbabu، نويسنده , , Vommina V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
3104
To page
3107
Abstract
Sequential combination of Ugi-MCR and click chemistry has been employed for the synthesis of triazole linked cyclic glycopeptidomimetics. The protocol employs Poc-amino alkyl isonitriles, sugar-1-amines, azido acids, and simple aldehydes as precursors. The dual nature of the propargyloxycarbonyl (Poc) group was explored for amine protection as well as cycloaddition with an azide. All the cyclic glycopeptidomimetics are isolated and characterized.
Keywords
Cyclic glycopeptidomimetic , Poc-amino alkyl isonitrile , Ugi multi-component reaction , click chemistry
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1880971
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