Title of article
Bis-imine primary amine protection of the dialkyltriamine, norspermidine
Author/Authors
Culf، نويسنده , , Adrian S. and Melanson، نويسنده , , Jennifer A. and Ouellette، نويسنده , , Rodney J. and Briand، نويسنده , , Glen G.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
3301
To page
3304
Abstract
This Letter details the particular use of salicylaldehyde (2-hydroxybenzaldehyde) for the regiospecific protection of primary amines in a representative polyamine, norspermidine (N-(3-aminopropyl)propane-1,3-diamine) under mild reaction conditions in high yield. The lack of intramolecular hexahydropyrimidine formation allowed for subsequent N2-acylation and N2-alkylation reactions, typical of polyamine synthetic strategies.
Keywords
polyamine , Imine , PROTECTION
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881043
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