Title of article
l-Proline-catalyzed diastereoselective synthesis of cis-isoquinolonic acids and evaluation of their neuroprotective effects
Author/Authors
Karimi، نويسنده , , Ali Reza and Momeni، نويسنده , , Hamid Reza and Pashazadeh، نويسنده , , Rahim، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2012
Pages
4
From page
3440
To page
3443
Abstract
l-Proline efficiently catalyzes the one-pot, three-component reaction of homophthalic anhydride, amines, and aldehydes in CH3CN at room temperature, to afford the corresponding cis-isoquinolonic acids in high yields and with excellent diastereoselectivities. The synthesized compounds are screened for neuroprotective activities.
Keywords
L-proline , Isoquinolonic acids , Multi-component reaction , diastereoselective synthesis , Neuroprotective effects
Journal title
Tetrahedron Letters
Serial Year
2012
Journal title
Tetrahedron Letters
Record number
1881096
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